CSS flexbox, also known as the Flexible Box Layout, is a layout model in CSS that allows for easy manipulation of the dimensions and alignment of a webpage’s items. The flexbox model gives more control over the alignment, direction, order, and size of these items within a container, even when their sizes are unknown or dynamic. This makes it particularly useful for creating responsive designs, as it simplifies the positioning of elements in various viewport sizes. Overall, it offers a more efficient way of laying out, aligning and distributing space among items in a container.